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Politically ambitious Amarillo police chief Jack McGinnis (William Fichtner) uses a local murder to gain votes in his campaign, a setback for Sheriff Buck Olmstead (R. Lee Ermey), up for re-election. The situation looks better for Olmstead after FBI agent Frank LaCrosse (Dennis Quaid) arrives to track the killer. LaCrosse has a personal agenda: he's convinced this killer is the man who kidnapped his son. Meanwhile, ex-medical student Lane Dixon (Jared Leto), hitchhiking across New Mexico, gets a lift from friendly Bob Goodall (Danny Glover), a former rail worker who later rescues Dixon from menacing miners in a bar.